Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization. Li Di, Edward H Kerns

Drug-Like-Properties.pdf
ISBN: 9780128010761 | 580 pages | 15 Mb

• Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
• Li Di, Edward H Kerns
• Page: 580
• Format: pdf, ePub, fb2, mobi
• ISBN: 9780128010761
• Publisher: Elsevier Science

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Overview

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

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How to Have Impossible Conversations: A Very Practical Guide. Peter Boghossian, James Lindsay

How-to-Have-Impossible.pdf
ISBN: 9780738285320 | 272 pages | 7 Mb

• How to Have Impossible Conversations: A Very Practical Guide
• Peter Boghossian, James Lindsay
• Page: 272
• Format: pdf, ePub, fb2, mobi
• ISBN: 9780738285320
• Publisher: Hachette Books

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Meditación para escépticos inquietos by Dan Harris, Jeff Warren, Carlye Adler

• Meditación para escépticos inquietos
• Dan Harris, Jeff Warren, Carlye Adler
• Page: 332
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• ISBN: 9786075277691
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You Will be Able to Draw by the End of this Book: Ink. Jake Spicer

You-Will-be-Able-to-Draw.pdf
ISBN: 9781781576533 | 160 pages | 4 Mb

• You Will be Able to Draw by the End of this Book: Ink
• Jake Spicer
• Page: 160
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• ISBN: 9781781576533
• Publisher: Octopus Books

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Star Wars: Droidography. Marc Sumerak

Star-Wars-Droidography.pdf
ISBN: 9780062862198 | 32 pages | 1 Mb

• Star Wars: Droidography
• Marc Sumerak
• Page: 32
• Format: pdf, ePub, fb2, mobi
• ISBN: 9780062862198
• Publisher: HarperCollins Publishers

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Star Wars: Droidography by Marc Sumerak Droids have always been at the heart of Star Wars, from the classic adventures of C-3PO and R2-D2 to the valiant exploits of BB-8 in the latest episodes of the saga. Droidography is the ultimate in-universe guide to these lovable characters with insider info on their function and role in the Star Wars universe. Covering every known model of droid, including free-rolling astromechs, protocol units, KX-series security models, and even bounty hunter droids, the book is filled with fascinating facts and insights that show just how crucial droids are to every faction in the galaxy, from the Rebellion to the First Order. With thrilling original illustrations and amazing special features including lift-the-flaps, textures, and more, Star Wars: Droidography is guaranteed to thrill the saga’s legions of young fans.

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Description. Droids have always been at the heart of Star Wars, from the classic adventures of C-3PO and R2-D2 to the valiant exploits of BB-8 in the latest 

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